Alpha Thalassemia Major is a serious hemoglobin disorder that occurs when the body is missing all four alpha-globin genes, essential for producing hemoglobin—the protein in red blood cells that carries oxygen. Without enough hemoglobin, the body can’t maintain healthy red blood cells, leading to severe anemia and inadequate oxygen supply to tissues. This condition is inherited in an autosomal recessive manner, meaning both parents must carry and pass down the defective gene. If both parents are carriers of the alpha-thalassemia trait, each child has a 25% chance of inheriting Alpha Thalassemia Major.
Signs and Symptoms
Treating Alpha Thalassemia Major in utero is crucial to preventing severe anemia and its complications, which can significantly affect the baby’s growth and development.
Intrauterine Blood Transfusions: This is the most common and effective in-utero treatment. Healthy red blood cells are transfused directly into the fetus's bloodstream through the umbilical vein. This procedure helps correct the severe anemia caused by the condition.
When you contact The Fetal Center, you will be in touch with a dedicated coordinator who will walk you through the process step-by-step and help you to understand every aspect of your care.
The Fetal Center at Children's Memorial Hermann Hospital
UT Professional Building
6410 Fannin, Suite 210
Houston, Texas 77030
Phone: (832) 325-7288
Toll free: (888) 818-4818
Fax: (713) 383-1464
Email: thefetalcenter@memorialhermann.org
To contact The Fetal Center at Children's Memorial Hermann Hospital, please fill out the form below.
Located within the Texas Medical Center, The Fetal Center is affiliated with McGovern Medical School at UTHealth Houston, UT Physicians and Children’s Memorial Hermann Hospital.